S18-04 Synchronization of oscillating cells during embryogenesis

نویسنده

  • Andrew Oates
چکیده

The ability to maintain a proportionate body plan in individuals of different sizes is essential for proper development. Despite wide interest, little is known about the mechanisms underlying scaling with size. I will discuss our efforts to reveal the molecular basis for scaling in different systems. A general ‘‘Expansion– Repression’’ feedback topology will be presented, which ensures scaling for a wide range of parameters and sizes through an effective implementation of an integral-feedback controller. Integralfeedback presents a key concept in engineering, and is likely to be instrumental also for maintaining biological homeostasis.

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عنوان ژورنال:
  • Mechanisms of Development

دوره 126  شماره 

صفحات  -

تاریخ انتشار 2009