The significance of KIT (CD117) in gastrointestinal stromal tumors.
نویسندگان
چکیده
can be found at: International Journal of Surgical Pathology Additional services and information for http://ijs.sagepub.com/cgi/alerts Email Alerts: http://ijs.sagepub.com/subscriptions Subscriptions: http://www.sagepub.com/journalsReprints.nav Reprints: http://www.sagepub.com/journalsPermissions.nav Permissions: http://ijs.sagepub.com/cgi/content/refs/12/2/93 SAGE Journals Online and HighWire Press platforms): (this article cites 22 articles hosted on the Citations
منابع مشابه
Histological and Immunological Evaluation of Gastrointestinal Stromal Tumors
Background: Gastrointestinal stromal tumors (GISTs) constitute the majority of gastrointestinal mesenchymal tumors. They usually express a proto-oncogen protein called CD117 detected by immunohistochemistry. This study investigated the differentiation of GISTs as well as the risk of aggressive behaviors in GISTs from surgically-treated patients in university affiliated hospitals. Methods: The c...
متن کاملDetermination of CD117 Expression in Glial Tumors and Its Comparison between High Grade and Low Grade Tumors
Background and Objective: Gliomas are the most common primary brain tumors. Despite therapeutic advances, the majority of gliomas do not respond to either chemo or radiotherapy. CD117, the gene product of c-kit has been expressed in cells of glial tumors. Because gastrointestinal stromal tumors (GISTs) that express CD117 respond dramatically to treatment with tyrosine kinase inhibitors, ide...
متن کاملGastrointestinal Stromal Tumor (GIST) with Chondroid-Myxoid-Chordoid Features Mimicking Extraskeletal Myxoid Chondrosarcoma
Epithelioid gastrointesinal tumors (GISTs) are less likely to have c-kit gene mutations (and express CD117) than spindle cell GISTs. CD117 negative/c-kit negative GISTs can have platelet-derived growth factor alpha (PDGFRα) gene mutations, overexpress PDGFRα protein and respond to imatinib mesylate. Many cases of CD117-negative/CD117weakly positive, c-kit mutation negative and PDGFRα mutation p...
متن کاملبررسی مورفولوژی و ایمونوهیستوشیمیایی تومورهای استرومایی لوله گوارش و ارزش بروز c-kit در تشخیص هیستومورفولوژیک آنها
Background & Aim: Gastrointestinal stromal tumors(GISTs) are the most common mesenchymal tumors of gastrointestinal tract. They are known to express c-kit, which is important in their diagnosis and treatment. The aim of our study was to assess the morphologic and immunohistochemical features of gastrointestinal stromal tumors and the significance of c-kit expression in them. Materials and M...
متن کاملCoexisting and possible primary extra-gastrointestinal stromal tumors of the pancreas and liver: A single case report.
Gastrointestinal stromal tumors (GIST) are mesenchymal neoplasms of the gastrointestinal tract (GI) that are defined, in part, by the expression of CD117, a c-Kit proto-oncogene protein. GISTs emerge outside of the GI at a very low frequency, typically in a single organ or location. GISTs that occasionally emerge outside of the GI are classified as extra-gastrointestinal stromal tumors (EGIST)....
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ورودعنوان ژورنال:
- International journal of surgical pathology
دوره 12 2 شماره
صفحات -
تاریخ انتشار 2004