A curated census of autophagy-modulating proteins and small molecules

A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy.

Autophagy, a programmed process in which cell contents are delivered to lysosomes for degradation, appears to have both tumor-suppressive and tumor-promoting functions; both stimulation and inhibition of autophagy have been reported to induce cancer cell death, and particular genes and proteins have been associated both positively and negatively with autophagy. To provide a basis for incisive a...

مروری بر کنترل اتوفاژی به وسیله ROS (گونه های فعال اکسیژن )

    ROS (Reactive Oxygen Species) are small, short-lived and highly reactive molecules that can oxidize proteins, lipids and DNA. ROS are formed by incomplete one-electron reduction of oxygen. ROS include oxygen anions, free radicals, including superoxide and hydroxyl radicals, and peroxides such as hydrogen peroxide (H2O2).  Autophagy is a catabolic pathway for degradation ...

P122: Small Molecules as Chemical and Pharmacological Tools for Neuroinflammatory Diseases Treatment (with Emphasis on Multiple Sclerosis)

Multiple Sclerosis (MS) is a neuroinflammatory disease resulting in degeneration of the myelin sheaths and death of oligodendrocytes. So far, several strategies have been introduced to control the disease. Treatment with small molecules is one of the strategies that have recently attracted the attention in the scientific community. These molecules that target epigenetic and other cellular proce...

INTERACTION OF PROTEINS WITH SMALL MOLECULES

Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers.

Autophagy is an intracellular degradation pathway essential for cellular and energy homoeostasis. It functions in the clearance of misfolded proteins and damaged organelles, as well as recycling of cytosolic components during starvation to compensate for nutrient deprivation. This process is regulated by mTOR (mammalian target of rapamycin)-dependent and mTOR-independent pathways that are amena...