Total syntheses of natural products containing spirocarbocycles.
نویسندگان
چکیده
The structures of natural products from a variety of sources contain spirocycles, two rings that share a common atom. The spiro motif is finding increasing inclusion in drug candidates, and as a structural component in several promising classes of chiral ligands used in asymmetric synthesis. Total syntheses of products containing all-carbon spirocycles feature several common methods of ring closure which we examine in this review.
منابع مشابه
Natural products containing 'decalin' motif in microorganisms.
Microorganisms are well-known producers of a wide variety of bioactive compounds that are utilized not only for their primary metabolism but also for other purposes such as defense, detoxification, or communication with other micro- and macro-organisms. Natural products containing a 'decalin ring' occur often in microorganisms. They exhibit diverse and remarkable biological activities, includin...
متن کاملRecent Synthetic Studies Leading to Structural Revisions of Marine Natural Products
Because of the highly unique structures of marine natural products, there are many examples of structures that were originally proposed based on spectral analyses but later proven incorrect. In many cases, the total syntheses of the originally proposed structures of marine natural products has confirmed their incorrectness and the subsequent total syntheses of the newly proposed structures prov...
متن کاملTotal syntheses of subereamollines A and B.
The first total syntheses of (+)- and (-)-subereamollines A and B are reported. The enantiomeric forms of the natural products were obtained by preparative chiral HPLC separation of the corresponding racemates.
متن کاملTotal Synthesis: A Crowning Achievement in Organic Chemistry
Discoveries in organic chemistry have had profound impacts in many disciplines of science through the past century. Within the field of organic chemistry, research in total synthesis of natural products has provided a means of developing and advancing the study of different types of chemistry. The discovery of novel chemical transformations, use of total synthesis products in biochemical assay ...
متن کاملTotal synthesis and biosynthesis of the paraherquamides: an intriguing story of the biological Diels-Alder construction.
The syntheses and biosyntheses of the paraherquamide and brevianamide families of prenylated indole-derived alkaloids are reviewed. It has been proposed that the unique bicyclo[2.2.2]diazaoctan ring system that is common to this family of natural products, arises by a biological intramolecular Diels-Alder cycloaddition reaction. Both synthetic approaches and total syntheses of several members o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 39 شماره
صفحات -
تاریخ انتشار 2015