Clinical Implications of Acquired Blood Coagulation Abnormalities.

C OMPLEX ALTERATION of blood coagulation occurs in the course of a number of systemic disorders. In contrast to the congenital defects of hemnostasis which are usually characterized by a single clotting factor deficiency, the changes which may accompany acquired disease are characteristicallv multiple. These multiple defects tend to form typical patterns which reflect the physiologic abnormality responsible for them. Accordingly,