Nitrimidazine compared with metronidazole in the treatment of vaginal trichomoniasis.
نویسندگان
چکیده
A new substituted nitroimidazole, nitrimidazine (Naxogin), is compared with the established drug, metronidazole (Flagyl), for the treatment of vaginal trichomoniasis in a randomized double-blind trial. Nitrimidazine cured 39 (68%) out of 57 patients and showed no undesirable effects other than nausea in one patient. Metronidazole cured 51 (89%) out of 57 patients and also caused nausea in one patient; this cure rate corresponds with that previously reported in other trials. In the recommended dosage nitrimidazine is inferior to metronidazole, but is sufficiently effective to be useful in cases of intolerance to metronidazole.
منابع مشابه
Detection of the antitrichomonal drug nitrimidazine (Naxogin) in urine.
For 10 years vaginal trichomoniasis has been treated by oral chemotherapy. Some cases appear not to respond satisfactorily to the drug used, and it is important to know whether or not the patient is taking the drug, and if so, whether or not it is being absorbed from the alimentary tract. A simple method for detecting these drugs in urine may be of use in such cases. Two antitrichomonal drugs i...
متن کاملComparison of nitrimidazine and metronidazole in the treatment of trichomonal vaginitis.
Until the introduction of metronidazole, the treatment of trichomonal vaginitis presented a considerable therapeutic problem. Local treatment was commonly followed by recurrence of the condition, doubtless partly because vaginal treatment alone failed to eliminate all foci of infection. Moreover, it became apparent that trichomonal infection was also often present in the male (Watt and Jennison...
متن کاملBacterial Vaginosis and Trichomoniasis: Epidemiology and Management of Recurrent Disease
Effective therapies exist for the treatment of both vaginal trichomoniasis and bacterial vaginosis (BV). Recurrent trichomonas infection is uncommon, and significant metronidazole resistance remains rare. The management of metronidazole-resistant trichomoniasis is dependent on susceptibility studies, which can be used to guide higher doses of metronidazole therapy. Recurrent BV is common. A mec...
متن کاملPrevalence of Trichomoniasis and Determination of in Vitro Susceptibility of Isolated Parasites to Metronidazole in Women Referred to Health Centers in Arak, Iran, in 2020
Background and Objective: Trichomoniasis is the most common sexually transmitted parasitic disease in the world. Due to its importance and the need for recognizing its prevalence and epidemiology, this study was conducted to determine the rate of T. vaginalis infection in women referred to Health Centers in Arak, Iran, in 2020. Materials and Methods: In this cross-sectional study, from 630 wom...
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ورودعنوان ژورنال:
- British medical journal
دوره 4 5780 شماره
صفحات -
تاریخ انتشار 1971