Simultaneous Retinal and Iris Metastases in Small Cell Lung Carcinoma

Metastatic carcinoma is the most common intraocular malignancy in the adult population, and the most common primary cancers are breast cancer, followed by lung cancer [1]. In all ocular metastases, uveal metastasis is the most common form. The choroid is the most common site for uveal metastasis [2]. Shah et al. [3] investigated 194 patients with uveal metastasis from lung cancer and found that the tumor locations included choroid (88%), iris (10%), and ciliary body (2%). Metastases to the retina, optic disc, and vitreous are rare [4]. Shields et al. [5] reported that, there were only 8 patients being diagnosed with retinal metastasis from systemic cancer during a 40-year period at an oncology referral center. Small cell lung carcinoma (SCLC) constitutes 14% of all lung cancers in the United States [6]. Its prognosis is significantly worse than non-small cell carcinoma because of the tendency of rapid growth and early and widespread dissemination. We are presenting an unusual case of 60-yearold male with SCLC who developed multiple ocular metastases in the retina and iris. We will highlight the clinical features of histopathology, immunohistochemistry, and spectral-domain optical coherence tomography (SD-OCT) in the ocular metastases from SCLC.