Bactericidal Effect of Phenoxazines Against Non-tuberculosis Mycobacteria
نویسندگان
چکیده
Produced by the Reactions with Bovine Hemo-globin Show Antimicrobial Activity Against Non-tuberculosis Mycobacteria. We studied the anti-microbial effects of phenoxazines produced by the reaction of o-aminophenol or its derivatives with bovine hemoglobin, on seven species of mycobacteria such as Mycobacterium tuberculosis , Mycobacterium marinum, Mycobacterium intracellulare, Mycobacterium scrofulaceum, Mycobacterium fortuitum, Mycobacterium kansasii and Mycobacteri-um smegmatis and some bacteria such as Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica serovar Typhimurium, Staphylococcus aureus, Listeria monocy-togeneses. These phenoxazines, including 2-amino-4, 4α-dihydro-4α , 7-dimethyl-3H-phenoxzine-3-one (Phx-1), 3-amino-1, 4α-dihydro-4α , 8-dimethyl-2H-phenoxazine-2-one (Phx-2), and 2-aminophenoxazine-3-one (Phx-3), prevented the proliferation of four non-tuberculosis mycobacteria including M. scrofulaceum, M. kansasii, M. marinum, and M. intracellulare dose-dependently, though the inhibitory effects of these phenoxazines differed according to the species of mycobacteria. However these phenoxazines failed to prevent the proliferation ofM. tuberculosis, M. fortuitum, and M. smegmatis, and the concerned bacteria other than mycobacteria. The present results may contribute to development of novel antibiotics against non
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