Acute Renal Failure Due to Membranoproliferative Glomerulonephritis and Kidney Tumoral Infiltration in a Patient with Mantle Cell Lymphoma
نویسندگان
چکیده
Mantle cell lymphoma (MCL)represents 5-10% of all B-cell non-Hodgkin lymphomas (NHL) and is characterized by the proliferation of mature B-lymphocytes, usually co expressing CD5, that infiltrate lymphoid tissues, bone marrow, peripheral blood, and extranodal sites [1]. Genetically, MCL is characterized by the t (11;14) (q13;32) translocation which leads to the rearrangement and over expression of the cyclin D1 gene [2,3]. From the clinical standpoint, MCL usually has an aggressive clinical course with short responses to treatment, frequent relapses, and short survival [4].
منابع مشابه
Acute renal failure due to renal lymphomatous infiltration as the initial manifestation
A male patient with acute renal failure (ARF) due to large B-cell non-Hodgkin lymphoma infiltration of kidney is presented. The diagnosis was suspected because of coincidence of ARF and tumor lysis syndrome non-responsive to conservative renal therapies. A renal biopsy confirmed diagnosis and appropriate chemotherapy led to complete improvement of renal function.
متن کاملNon Hodgkin's lymphoma associated membranoproliferative glomerulonephritis: rare case of long term remission with chemotherapy: a case report
INTRODUCTION Although membranoproliferative glomerulonephritis has been reported to occur in association with non-Hodgkin's lymphoma, information concerning the long term effects of treatment of non-Hodgkin's lymphoma on the associated membranoproliferative glomerulonephritis is limited. CASE PRESENTATION The current report describes a patient who presented with the abrupt onset of hypertensi...
متن کاملAntineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis associated with mantle cell lymphoma
Renal involvement in non-Hodgkin lymphoma, especially mantle cell lymphoma (MCL) is rare. A 77-year-old man presented with acute kidney injury (AKI), which rapidly progressed to dialysis dependence. Kidney biopsy revealed patchy B-cell lymphocytic aggregates in the interstitium, which were positive for cyclin D1, consistent with atypical CD5-negative MCL as confirmed by the detection of translo...
متن کاملRenal Involvement in Non-Hodgkin Lymphoma: Proven by Renal Biopsy
AIMS To determine the spectrum of renal lesions in patients with kidney involvement in non-Hodgkin's lymphoma (NHL) by renal biopsy. METHODS The clinical features and histological findings at the time of the renal biopsy were assessed for each patient. RESULTS We identified 20 patients with NHL and renal involvement, and the diagnosis of NHL was established following the kidney biopsy in 18...
متن کاملSplenic Marginal Zone Lymphoma and Concurrent Membranoproliferative Glomerulonephritis With IgMKappa Deposits in a HCV-Seropositive Patient
We report a case of membranoproliferative glomerulonephritis (MPGN) with IgMκ light chain deposits in a patient with chronic hepatitis C infection and simultaneous onset of monoclonal IgMκ gammopathy with concurrent small B-cell lymphoproliferative disease. The patient presented with hepatosplenomegaly and a uremic state that necessitated dialysis without any clinical signs of systemic disease ...
متن کامل