Research Article

Liposomes, which are biodegradable and essentially non-toxic vehicles, can encapsulate both hydrophilic and hydrophobic materials, and are utilized as drug carriers in drug delivery systems. Stealth liposomes are surface modified liposomes in which PEG units are attached to the outer surface of liposome units, so that they can escape the opsonization effect in the blood, which is a major cause for decreased drug availability at its site of action. Pegylated liposomes are longcirculating with improved bioavailability and sustained action of loaded drug molecules. The aim of this study was to formulate and evaluate Stealth liposomal drug delivery system of Zidovudine antiretroviral drug, the first one approved for treatment of HIV. Zidovudines Stealth Liposomes are prepared by lipid hydration technique using rotary flash evaporator. The prepared liposomes were characterized by optical microscopy, scanning electron microscopic method respectively.