Continuous two-dimensional current source density analyses of electrophysiological activity in hippocampal slices

The well-studied methods of current source density analysis use the Laplacian transform to identify locations and relative magnitudes of current sources and sinks. The method is typically used in reduced one-dimensional form for electrophysiological measures, due to technical limitations. The present paper outlines a two-dimensional method in which simultaneous samples are recorded from multiple electrodes in an equidistant array, enabling the continuous sensing of current #ows in any direction within the plane of the slice. This method reveals spatial aspects of the current sources and sinks that are di$cult to discern by other means. 2001 Elsevier Science B.V. All rights reserved.