Clinical changes induced by allergen immunotherapy with dermatophagoides pteronyssinus in local allergic rhinitis

نویسندگان

  • Carmen Rondon
  • Paloma Campo
  • Maria Jose Torres
  • Luisa Galindo
  • Natalia Blanca-Lopez
  • Gabriela Canto
  • Cristobalina Mayorga
  • Miguel Blanca
چکیده

Methods Thirty-six subjects with LAR to DP were selected to participate in a double-blind, placebo-controlled, parallelgroup, phase II clinical trial of subcutaneous AIT in LAR. The patients were randomized to receive AIT-DP with Pangramin PLUS, ALK, DP, or placebo for a period of 24 months. The primary endpoint was total symptoms (TSS) and total medication scores (TMS). Secondary endpoints were: total combined symptom+medication scores (TCS), daily symptoms score (DSS), daily medication score (DMS), medication free days (MFD), skin testing, nasal allergen provocation test (NAPT-DP), and adverse events. Serum and nasal lavage samples were obtained for immunological studies.

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عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2015