Drug - Drug Solid Dispersion: A Unique Approach in Solubility Enhancement

Over 40% of active pharmaceutical ingredients in development are poorly water soluble drugs which limit formulation approaches, clinical application and marketability because of their low dissolution and bioavailability. Solid dispersion has been considered one of the major advancements in overcoming these issues with several successfully marketed products. Extensive review of the literature indicates that physiological inert carriers have so far been used in solid dispersions for improving dissolution of poorly soluble drugs but in, novel approach will obviate the need for use of physiological inert carrier to improve dissolution of poorly soluble drugs and cost effective in developing formulations for clinical