Crebh, A Novel Liver Clock Keeper For Energy Metabolism
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چکیده
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منابع مشابه
CREBH Couples Circadian Clock With Hepatic Lipid Metabolism
The circadian clock orchestrates diverse physiological processes critical for health and disease. CREB, hepatocyte specific (CREBH) is a liver-enriched, endoplasmic reticulum (ER)-tethered transcription factor known to regulate the hepatic acute phase response and energy homeostasis under stress conditions. We demonstrate that CREBH is regulated by the circadian clock and functions as a circadi...
متن کاملCREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis.
Cyclic AMP-responsive element binding protein, hepatocyte specific (CREBH), is a liver-enriched, endoplasmic reticulum-tethered transcription factor known to regulate the hepatic acute-phase response and lipid homeostasis. In this study, we demonstrate that CREBH functions as a circadian transcriptional regulator that plays major roles in maintaining glucose homeostasis. The proteolytic cleavag...
متن کاملLoss of Transcription Factor CREBH Accelerates Diet-Induced Atherosclerosis in Ldlr-/- Mice.
OBJECTIVE Liver-enriched transcription factor cAMP-responsive element-binding protein H (CREBH) regulates plasma triglyceride clearance by inducing lipoprotein lipase cofactors, such as apolipoprotein A-IV (apoA-IV), apoA-V, and apoC-II. CREBH also regulates apoA-I transcription. This study aims to determine whether CREBH has a role in lipoprotein metabolism and development of atherosclerosis. ...
متن کاملThe CREBH in hepatic lipid and lipoprotein metabolism: Implication for the pathogenesis of hyperlipidemia and metainflammation
Zhao, Miaoyun, "The CREBH in hepatic lipid and lipoprotein metabolism: Implication for the pathogenesis of hyperlipidemia and metainflammation" (2014). The CREBH in hepatic lipid and lipoprotein metabolism: Implication for the pathogenesis of hyperlipidemia and metainflammation The CREBH in hepatic lipid and lipoprotein metabolism: Implication for the pathogenesis of hyperlipidemia and metainfl...
متن کاملIdentification and Characterization of Cyclic AMP Response Element-Binding Protein H Response Element in the Human Apolipoprotein A5 Gene Promoter
The cyclic AMP response element-binding protein H (CREBH) plays important roles in hepatic lipogenesis, fatty acid oxidation, and lipolysis under metabolic stress. Here, we report CREBH as a novel regulator of human APOA5. Knockdown of endogenous CREBH expression via small interfering RNA resulted in the downregulation of human APOA5 mRNA expression in human hepatoma cells, HepG2. Sequence anal...
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