Functional Build-in Template Directed Siliceous Fluorescent Supramolecular Vesicles as Diagnostics

Functional template directed synthesis of hybrid siliceous fluorescent vesicle (HSFV) is fabricated by using fluorescent vesicle as a build-in template. The template vesicle is the ionic self-assembly of an aggregation-induced emission (AIE) fluorogen. Upon depositing folic acid modified silica shell on its surface, the obtained HSFVs display low cytotoxicity, significant fluorescence and targeted drug delivery toward cancer cells. Furthermore, the wall-thickness of the HSFVs can be controlled via altered concentration of silica source. This is the first report of HSFV employing the template vesicle as a build-in fluorescent agent, which represents a good example of rational design for an effective diagnostics, and may open up a new avenue for precision medicine. Keyword: hybrid self-assembly, aggregation-induced emission, template, fluorescent vesicles, precision medicine *Correspondence: [email protected], [email protected], [email protected], [email protected] # These authors contribute equally.