Commentary: XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
نویسندگان
چکیده
Center for Geroscience, Brain Health and Metabolism, Santiago, Chile, 2 Biomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile, 3 Program of Cellular and Molecular Biology, Institute of Biomedical Sciences, University of Chile, Santiago, Chile, Center for Integrative Biology, Universidad Mayor, Santiago, Chile, Buck Institute for Research on Aging, Novato, CA, USA, Department of Immunology and Infectious diseases, Harvard School of Public
منابع مشابه
XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity
The ability to ensure proteostasis is critical for maintaining proper cell function and organismal viability but is mitigated by aging. We analyzed the role of the endoplasmic reticulum unfolded protein response (UPR(ER)) in aging of C. elegans and found that age-onset loss of ER proteostasis could be reversed by expression of a constitutively active form of XBP-1, XBP-1s. Neuronally derived XB...
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X-box binding protein-1 (XBP-1) is an important regulator of a subset of genes during endoplasmic reticulum (ER) stress. In the current study, we analyzed endogenous XBP-1 expression and localization, with a view to determining the effects of ER stress on the developmental competency of preimplantation embryos in mice. Fluorescence staining revealed that functional XBP-1 is localized on mature ...
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