An Appraisal on the Degradation of Paracetamol by TiO2/UV System in Aqueous Medium. Product Identification by Gas Chromatography-Mass Spectrometry (GC-MS)
نویسنده
چکیده
A oxidação do paracetamol (1) promovida pelo sistema TiO 2 /UV em meio aquoso foi investigada. O contínuo monitoramento feito por várias técnicas, tais como espectroscopia UVVis, HPLC (cromatografia líquida de alta eficiência), TOC (carbono orgânico total) e ESI-MS (espectrometria de massas com ionização electrospray), mostrou que a remoção do paracetamol foi altamente eficiente, mas com um grau reduzido de mineralização. As análises por GC-MS (cromatografia a gás acoplada a um espectrômetro de massas) indicaram que hidroquinona, ácidos carboxílicos alifáticos, e paracetamol mono e dihidroxilados são os principais produtos formados neste processo de degradação. De acordo com estes resultados, uma rota para degradação do paracetamol induzida pelo sistema TiO 2 /UV foi proposta. A fragmentação dos derivados trimetilsililados (TMS) do monohidróxi e dihidróxi paracetamol, baseada em dados dos espectros de massas, foi também proposta.
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