Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacologic approach
نویسندگان
چکیده
Department of Medical Oncology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA; Department of Medicine and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA; ActivX Biosciences, Inc., La Jolla, CA; Lurie Family Imaging Center, Dana-Farber Cancer Institute, MA; Chemical Kinomics Research Center, Korea Institute of Science and Technology, Seoul, Korea; and KU-KIST Graduate School of Converging Science and Technology, Seongbuk-gu, Seoul, Korea
منابع مشابه
Identification of novel therapeutic targets in acute leukemias with NRAS mutations using a pharmacological approach
متن کامل
Human Cancer Modeling: Recapitulating Tumor Heterogeneity Towards Personalized Medicine
Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...
متن کاملHuman Cancer Modeling: Recapitulating Tumor Heterogeneity Towards Personalized Medicine
Despite diagnostic, preventive and therapeutic advances, growing incidence of cancer and high rate of mortality among patients affected by specific cancer types indicate current clinical measures are not ideally useful in eradicating cancer. Chemoresistance and subsequent disease relapse are believed to be mainly driven by the cell-molecular heterogeneity of human tumors that necessitates perso...
متن کاملThe Impact of FLT3 Mutations on the Development of Acute Myeloid Leukemias
The development of the genetic studies on acute myeloid leukemias (AMLs) has led to the identification of some recurrent genetic abnormalities. Their discovery was of fundamental importance not only for a better understanding of the molecular pathogenesis of AMLs, but also for the identification of new therapeutic targets. In this context, it is essential to identify AML-associated "driver" mut...
متن کاملETV6 mutations in early immature human T cell leukemias
Early immature T cell acute lymphoblastic leukemias (T-ALLs) account for ~5-10% of pediatric T-ALLs and are associated with poor prognosis. However, the genetic defects that drive the biology of these tumors remain largely unknown. In this study, analysis of microarray gene expression signatures in adult T-ALL demonstrated a high prevalence of early immature leukemias and revealed a close relat...
متن کامل