A Novel Tissue Protective Peptide: Cyclic Helix B Peptide
نویسندگان
چکیده
Renal transplantation is one of the best choices for the treatment to the end stage renal disease. However, the shortage of the donor organs is a worldwide challenge, and the huge demand for transplantation forced the widely use of organs from expanded criteria donors or donation after cardiac death. Kidneys from these donors are highly sensitive to ischemia reperfusion (IR) injury, which might cause delayed graft function and affects both shortand long-term graft survival. Since IR injury is inevitable during kidney transplantation, it is urgent to develop an effective drug to optimize the organ preservation and ameliorate the tissue injury.
منابع مشابه
Physicochemical study on some cycloltexa peptide nano rings at body normal temperature; novel biodegradable and biocompadble vectors in drug delivery
Nanopartmles have been used as an approach to improve the pharmacodynamic and phannacokinetie propertiesof various drues. Amino acids have been considered to be useful to make such nano particles because ofthocompatithe and biodegradable characteristic. The quantum mechanical method that was chosen to analyze inethio hexa peptide nano ring]. The structure of some peptide nanorrigs as well as th...
متن کاملNonerythropoietic, tissue-protective peptides derived from the tertiary structure of erythropoietin.
Erythropoietin (EPO), a member of the type 1 cytokine superfamily, plays a critical hormonal role regulating erythrocyte production as well as a paracrine/autocrine role in which locally produced EPO protects a wide variety of tissues from diverse injuries. Significantly, these functions are mediated by distinct receptors: hematopoiesis via the EPO receptor homodimer and tissue protection via a...
متن کاملDiscovery of Novel Peptidomimetics for Brain-Derived Neurotrophic Factor using Phage Display Technology
Brain-Derived Neurotrophic Factor (BDNF) is a neuroprotectant candidate for neurodegenerative diseases. However, there are several clinical concerns about its therapeutic applications. In the current study, we selected BDNF-mimicking small peptides from phage-displayed peptide library as alternative molecules to the clinical challenges. The peptide library was screened against BDNF receptor (Ne...
متن کاملNon-erythropoietic tissue-protective peptides derived from erythropoietin: WO2009094172.
Erythropoietin (EPO) is a cytokine with erythropoietic and tissue protective activities. Its action as a tissue protective agent requires, however, high dosage that results in limiting side effects associated with abnormally augmented erythropoiesis. Elimination of the erythropoietic activity of EPO while preserving its tissue protective properties was nevertheless achieved in carbamoylated EPO...
متن کاملSerological Detection of FMD Serotypes by New Prepared Innovative Recombinant Hepta-Epitopic Peptide
Background: Foot-and-mouth disease (FMD) is a highly contagious and economically important disease that affects cloven-hoofed animals worldwide. In recent years, a series of outbreaks of FMD have occurred in many countries. Recombinant protein synthesis incorporating protective B- and T-cell epitopes are candidates for new safer and more effective (FMD) vaccines that have potential to provide p...
متن کامل