CALL FOR PAPERS Biology of the Central Cilium and Cystic Diseases of the Kidney Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle
نویسندگان
چکیده
Robert Radford, Craig Slattery, Paul Jennings, Oliver Blacque, Walter Pfaller, Hans Gmuender, Joost Van Delft, Michael P. Ryan, and Tara McMorrow UCD School of Biomolecular and Biomedical Research, UCD Conway Institute, University College Dublin, Dublin, Ireland; Division of Physiology, Department of Physiology and Medical Physics, Innsbruck Medical University, Innsbruck, Austria; Genedata, Basel, Switzerland; and Netherlands Toxicogenomics Centre (NTC), Department of Human Biology, Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands
منابع مشابه
A finite elements study on the role of primary cilia in sensing mechanical stimuli to cells by calculating their response to the fluid flow
The primary cilium which is an organelle in nearly every cell in the vertebrate body extends out of the cell surface like an antenna and is known as cell sensor of mechanical and chemical stimuli. In previous numerical simulations, researchers modeled this organelle as a cantilevered beam attached to the cell surface. In the present study, however, we present a novel model that accommodates for...
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Tubular epithelial cells in the kidney are continuously exposed to urinary fluid shear stress (FSS) generated by urine movement and recent in vitro studies suggest that changes of FSS could contribute to kidney injury. However it is unclear whether FSS alters the epithelial characteristics of the renal tubule. Here, we evaluated in vitro and in vivo the influence of FSS on epithelial characteri...
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For quite some time the field of polycystic kidney disease has led a life at the fringe of kidney research, but with the cloning of the PKD1 and many other genes this situation has dramatically changed. Polycystic kidney disease often is a syndromic disease affecting a variety of organs in addition to the kidney. Most of the proteins involved in polycystic kidney disease have been localized to ...
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