Regular paper CD40 stimulation induces differentiation of acute lymphoblastic leukemia cells into dendritic cells
نویسندگان
چکیده
1Department of Pediatric Oncology, 2Department of Flow Cytometry, 3Department of Cytogenetics, 6Department of Nuclear Medicine, 7Students Scientific Section at the Department of Pediatric Oncology, Medical University of Białystok, Poland; 4Department of Pediatrics, Hematology and Oncology, Medical University of Warsaw, Poland; 5Department of Pediatric Hematology and Oncology, Medical University of Lublin, Poland; 1⁄2e-mail: [email protected]
منابع مشابه
CD40 stimulation induces differentiation of acute lymphoblastic leukemia cells into dendritic cells.
UNLABELLED Despite the very high percentage of long-term remissions in acute lymphoblastic leukemia (ALL) in children, some of them suffer from recurrence of the disease. New treatment modalities, e.g. effective geno- and immunotherapy are needed. The use of neoplasmatic cells to present tumor antigens is one of the approaches in cancer vaccines. ALL cells lack the expression of costimulatory m...
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The use of cancer vaccines based on dendritic cells (DC) presenting tumor antigens can be a promising tool in the treatment of leukemia. The functional characteristics of leukemia derived DC is still to be elucidated. CD40 promotes survival, proliferation and differentiation of normal B cells. CD40 triggering was used to enhance the poor antigen-presenting capacity of leukemic B-cells. Since it...
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Induction of Tolerogenic Murine Dendritic Cells by Downregulating the Co-stimulatory Molecule of CD40 Using Lentivirus Vector Mahmoodzadeh A1, Pourfatollah AA1, Karimi MH2, Moazzeni SM1 1Dept. of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran 2Transplantation Research Center, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran. Correspond Aut...
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