Convex Max-Product Algorithms for Continuous MRFs with Applications to Protein Folding
نویسندگان
چکیده
This paper investigates convex belief propagation algorithms for Markov random fields (MRFs) with continuous variables. Our first contribution is a theorem generalizing properties of the discrete case to the continuous case. Our second contribution is an algorithm for computing the value of the Lagrangian relaxation of the MRF in the continuous case based on associating the continuous variables with an ever-finer interval grid. A third contribution is a particle method which uses convex max-product in re-sampling particles. This last algorithm is shown to be particularly effective for protein folding where it outperforms particle methods based on standard max-product resampling.
منابع مشابه
Hinge-Loss Markov Random Fields and Probabilistic Soft Logic
This paper introduces hinge-loss Markov random fields (HL-MRFs), a new class of probabilistic graphical models particularly well-suited to large-scale structured prediction and learning. We derive HL-MRFs by unifying and then generalizing three different approaches to scalable inference in structured models: (1) randomized algorithms for MAX SAT, (2) local consistency relaxation for Markov rand...
متن کاملLinear Objective Function Optimization with the Max-product Fuzzy Relation Inequality Constraints
In this paper, an optimization problem with a linear objective function subject to a consistent finite system of fuzzy relation inequalities using the max-product composition is studied. Since its feasible domain is non-convex, traditional linear programming methods cannot be applied to solve it. We study this problem and capture some special characteristics of its feasible domain and optimal s...
متن کاملProteins, Particles, and Pseudo-Max-Marginals: A Submodular Approach
Variants of max-product (MP) belief propagation effectively find modes of many complex graphical models, but are limited to discrete distributions. Diverse particle max-product (D-PMP) robustly approximates max-product updates in continuous MRFs using stochastically sampled particles, but previous work was specialized to treestructured models. Motivated by the challenging problem of protein sid...
متن کاملEfficient Max-Margin Learning in Laplacian MRFs for Monocular Depth Estimation
While designing a Markov Random Field, especially one with continuous states such as in the task of depth estimation, one is presented with the modeling choice of what distribution to use. While distributions such as Gaussian are easy to work with, because of tractable inference and learning, they often do not model the data well. In particular, the statistics of natural images are heavy-tailed...
متن کاملProtein Stability, Folding, Disaggregation and Etiology of Conformational Malfunctions
Estimation of protein stability is important for many reasons: first providing an understanding of the basic thermodynamics of the process of folding, protein engineering, and protein stability plays important role in biotechnology especially in food and protein drug design. Today, proteins are used in many branches, including industrial processes, pharmaceutical industry, and medical fields. A...
متن کامل