Bilateral diffuse uveal melanocytic proliferation with a positive ophthalmoscopic and visual response to plasmapheresis.

unifocality, negative family history, and the absence of large dilated tortuous feeder vessels. The exact cause is unknown, although it has been proposed that they could be expressions of vascularization of pigment epithelial proliferation or reactive gliosis. We postulate that in the setting of chronic ROP and familial exudative vitreoretinopathy, there is retinal ischemia that produces a microenvironment conducive to vascular proliferation. Ophthalmologists who care for patients with a history of ROP should be aware of this late sequela because it is responsive to treatmentandmaycauseadditionalvision loss. This lesion may be underreported because it may be difficult to identify inthesettingof fibroticresiduaandtractional elements. We recommend fluorescein angiography if new retinal thickening or exudates are seen in order to identify treatable lesions. In this case, we were able to identify the lesion before massive exudation occurred. Treatment options include laser photocoagulation, cryotherapy, photodynamictherapy,and,morerecently,antivascularendothelial growth factor such as bevacizumab.