Topiramate for migraine prophylaxis.
نویسندگان
چکیده
Topiramate is a neurmodulatory compound with neuron stabilizing properties and is approved for the preventive treatment of migraine in several countries [5]. Several small and large trials have reported good efficacy and safety of topiramate in migraine prophylaxis in adults [6]. The present study was done to study the role of topiramate in migraine prophylaxis in children who either failed to respond to or were intolerant to other prophylactic medications used for migraine.
منابع مشابه
بررسی میزان اثربخشی توپیرامات در بهبود سردردهای میگرنی
Abstract Background: Several studies suggest improvements in quality of life in migraine patients with topiramate. MIDAS (Migraine Disability Assessment) and HIT6 (Headache Impact Test) are two questionnaires for evaluating migraine severity. The aim of this study was to assess the efficacy of Topiramate 100 mg/day in control and prophylaxis of migraine headache. Materials and methods: Eigh...
متن کاملEfficacy of Topiramate in Migraine Prophylaxis: a Randomized Controlled Study*
Topiramate has been under investigation for the past several years as a prophylactic agent for migraine and other headache disorders. Studies to date have shown it to be safe and effective. As with other antiepileptic drugs, its exact mechanisms of action are not yet known, or at least, the mechanisms that are important in its efficacy in migraine are not yet defined. Topiramate acts on several...
متن کاملFactors Associated with Favorable Outcome of Topiramate Migraine Prophylaxis in Pediatric Patients
BACKGROUND AND PURPOSE There are few studies that have investigated predictive factors related to migraine prophylaxis of which produced inconsistent results. The aim of this study was to identify factors that can predict the treatment response to topiramate prophylaxis in pediatric patients with migraine. METHODS One hundred and thirteen patients who were older than 7 years and received topi...
متن کاملTopiramate as Migraine Prophylaxis in Pediatric Patients: An Integrated Summary of Randomized Controlled Trials
Background: An integrated analysis of five randomized, placebo-controlled studies in migraine prophylaxis was conducted to assess topiramate’s efficacy and safety in pediatric patients. Methods: Study 1, a pivotal study (50-, 100 mg/day; aged 12-17 years), Study 2 (flexibly-dosed 2-3 mg/kg/day; aged 6-15 years), and Studies 3, 4 and 5 [50-, 100-, 200 mg/day; aged ≥ 12 years)]. Results: Percent ...
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Migraine prophylaxis represents a better choice than symptomatic drugs, both for safety and for effectiveness. Today, drugs such as calcium channel blockers, beta-blockers, and topiramate are still used to treat migraine with and without aura, often with satisfactory results but in some cases with adverse effects, thus limiting their use. A new class of drugs in migraine prophylaxis are endocan...
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ورودعنوان ژورنال:
- Indian pediatrics
دوره 49 4 شماره
صفحات -
تاریخ انتشار 2012