Xlvii. the Heat Inactivation of Diphtheria Antitoxin
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Studies on the denaturation of antibody; the influence of pH and certain other factors on the rate of inactivation of Staphylococcus antitoxin in urea solutions.
In previous work on the denaturation of antibody, studies have been made of some of the factors influencing the inactivation of diphtheria antitoxin in urea solutions (1, 2). A quantitative formulation of a simple kinetic theory was found to fit satisfactorily the experimental data and to offer a reasonable explanation of the deviation of the inactivation from simple first order behavior (2). I...
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Although in a recent study (1) the susceptibility of diphtheria antitoxin to the denaturing action of urea was apparently established, the question of the fundamental nature of the reaction remains essentially unsolved. Since the action of urea probably involves a partial unfolding of the polypeptide chains of proteins, the lability of antibody in urea suggests that the antibody structure resid...
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1. Collodion particles adsorb diphtheria or tetanus or botulinus toxins. These toxins are retained on the particles when washed but are at least in part released in the animal. 2. The adsorbed toxins are neutralized by adsorption of the corresponding antitoxins but are unaffected by other serums. 3. When collodion particles are treated first with tetanus antitoxin, then with diphtheria toxin, t...
متن کاملSialidase (neuraminidase) of Corynebacterium Diphtheriae.
Warren, Leonard (National Institute of Arthritis and Metabolic Diseases, Bethesda, Md.) and C. W. Spearing. Sialidase (neuraminidase) of Corynebacterium diphtheriae. J. Bacteriol. 86:950-955. 1963.-The characteristics of a sialidase produced by Corynebacterium diphtheriae were studied. The enzyme was partially purified from preparations of diphtheria toxin on a column of Sephadex G-75. By this ...
متن کاملAdjuvanticity of pGPL-Mc and LRS in the immune responses of monkeys to oral immunization with diphtheria and tetanus toxoids.
Experiments were carried out to examine the adjuvanticity of polar glycopeptidolipids of Mycobacterium chelonae (pGPL-Mc) or the London rocket seed (LRS) when combined with diphtheria and tetanus toxoids in an oral immunization of the African green monkey. The results showed that none of the monkeys receiving diphtheria and tetanus toxoids combined with 25 mg/kg of pGPL-Mc showed an increase in...
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