Molecular Imaging of Ovarian Carcinoma Angiogenesis PRINCIPAL INVESTIGATOR:
نویسنده
چکیده
منابع مشابه
TITLE: Early Detection of Ovarian Cancer by Molecular Targeted Ultrasound Imaging Together with Serum Markers of Tumor-Associated Nuclear Change and Angiogenesis PRINCIPAL INVESTIGATOR:
Tumor-associated neoangiogenesis (TAN) is an early event in ovarian cancer (OVCA) development. Increased expression of vascular endothelial growth factor receptor 2 (VEGFR2) by TAN vessels presents a potential target for early detection by ultrasound imaging. The goal of this study was to examine the suitability of VEGFR2-targeted ultrasound imaging agents in detecting spontaneous OVCA in layin...
متن کاملDAMD 17 - 03 - 1 - 0078 TITLE : SDF - 1 , DC 1 / DC 2 , and Tumor Angiogenesis PRINCIPAL INVESTIGATOR :
Ovarian carcinomas have a poor prognosis, often associated with multifocal i.p. dissemination accompanied by intense neovascularization. To examine tumor angiogenesis in the tumor microenvironment, we studied malignant ascites and tumors of patients with untreated ovarian carcinoma. We observed that malignant ascites fluid induced potent in vivo neovascularization in Matrigel assay. We detected...
متن کاملMagnetic resonance imaging visualization of hyaluronidase in ovarian carcinoma.
Hyaluronan, a high molecular weight, negatively charged polysaccharide, is a major constituent of the extracellular matrix. High molecular weight hyaluronan is antiangiogenic, but its degradation by hyaluronidase generates proangiogenic breakdown products. Thus, by expression of hyaluronidase, cancer cells can tilt the angiogenic balance of their microenvironment. Indeed, hyaluronidase-mediated...
متن کاملMagnetic Resonance Imaging Visualization of Hyaluronidase
Hyaluronan, a high molecular weight, negatively charged polysaccharide, is a major constituent of the extracellular matrix. High molecular weight hyaluronan is antiangiogenic, but its degradation by hyaluronidase generates proangiogenic breakdown products. Thus, by expression of hyaluronidase, cancer cells can tilt the angiogenic balance of their microenvironment. Indeed, hyaluronidase-mediated...
متن کامل