Histological metrics confirm microstructural characteristics of NODDI indices in multiple sclerosis spinal cord
نویسندگان
چکیده
Francesco Grussu, Torben Schneider, Richard L. Yates, Mohamed Tachrount, Jia Newcombe, Hui Zhang, Daniel C. Alexander, Gabriele C. DeLuca, and Claudia A. M. Wheeler-Kingshott NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, England, United Kingdom, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, England, United Kingdom, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, England, United Kingdom, NeuroResource, UCL Institute of Neurology, London, England, United Kingdom, Department of Computer Science and Centre for Medical Image Computing, University College London, London, England, United Kingdom
منابع مشابه
Neurite dispersion: a new marker of multiple sclerosis spinal cord pathology?
OBJECTIVE Conventional magnetic resonance imaging (MRI) of the multiple sclerosis spinal cord is limited by low specificity regarding the underlying pathological processes, and new MRI metrics assessing microscopic damage are required. We aim to show for the first time that neurite orientation dispersion (i.e., variability in axon/dendrite orientations) is a new biomarker that uncovers previous...
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