Children with Nephrotic Syndrome Suffer from Cerebral Venous Thrombosis
نویسندگان
چکیده
Hypercoagulability is a common complication in children with nephrotic syndrome and may cause venous thrombosis. This study explored the effectiveness of urokinase and low-molecular-weight (LMW) heparin used in conjunction in seven children with nephrotic syndrome complicated by intracranial venous thrombosis. The urokinase dose was 2,000-4,000 u/kg/day initially, with a pulse dose of 20,000-40,000 u given within 15-30 minutes and the remainder was pump-infused. From day 2, a dose of 2,000 u/kg/day was infused via the pump, and the total course duration was 3 to 7 days. During treatment, thrombin time (TT) and activated partial thromboplastin time (APTT) were tested three times per week, and particular attention was given to any bleeding. LMW heparin was used at a dosage of 100-120 anti-Xa IU/kg once or twice per day, given by abdominal subcutaneous injection for two weeks. The antiplatelet drug, dipyridamole 3-5 mg/kg, was also given orally two or three times per day for three months. In this study, the early use of urokinase, LMW heparin and anti-platelet drugs had good effect, the need for preventive therapy and early diagnosis of this complication in nephrotic syndrome should be given wider clinical consideration. *Corresponding authors: Zheng-Kun Xia, Department of Pediatrics, Nanjing Jinling Hospital, 305 East Road, Zhong Shan, Nanjing 210002, P.R. China, Tel: (+86 25) 80861386; E-mail: [email protected] Xiao Yang, Department of Pediatrics, Nanjing Jinling Hospital, 305 East Road ZhongShan, Nanjing 210002,P.R.China. Tel: (+86 25) 80861386; E-mail: [email protected] Zhongmin Fan, Department of Pediatrics, Nanjing Jinling Hospital, 305 East Road ZhongShan, Nanjing 210002,P.R.China. Tel: (+86 25) 80861386; E-mail: [email protected] Yuanfu Gao, Department of Pediatrics, Nanjing Jinling Hospital, 305 East Road ZhongShan, Nanjing 210002,P.R.China. Tel: (+86 25) 80861386; E-mail: [email protected] Received January 03, 2014; Accepted February 18, 2014; Published February 25, 2014 Citation: Xia ZK, Yang X, Fan ZM, Gao YF, Gao C, et al. (2014) Children with Nephrotic Syndrome Suffer from Cerebral Venous Thrombosis. J Nephrol Therapeutic S11: 005. doi:10.4172/2161-0959.S11-005 Copyright: © 2014 Xia ZK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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