Association of Hyperglycemia, Hyperlipemia with the Risk of Uterine Leiomyomata: A Case-Control Study

Uterine leiomyoma are common noncancerous tumors of the uterus and are the most frequent reason for recommending a hysterectomy. This study was conducted to investigate the associations between uterine leiomyoma and lifestyles including glucose metabolism, lipid metabolism and obesity. The case-control study was conducted from January 1st 2012 to December 31st 2012 at Yuhuangding Hospital in Yantai. All Uterine fibroid patients were confirmed by postoperative pathology. This case-control study composed of 165 cases and 165 controls. The adjusted odds ratio (OR) and 95% confidence interval (CI) were estimated using unconditional logistic regression. For premenopausal women, fasting plasma glucose (FPG) (OR=0.09; 95% CI: 0.003-0.029) and HDL-C/LDL-C (OR=0.01; 95% CI: 0.002-0.114) significantly decreased the risk of uterine leiomyoma. Conversely, total cholesterol (TC) (OR=6.70; 95% CI: 3.816-11.764) and body mass index (BMI) (OR=1.36; 95% CI: 1.226-1.517) significantly increased the risk. This study suggested protective roles for higher level of HDL-C and FPG on uterine leiomyoma, and supported the hypothesis that lower level of TC and BMI may reduce uterine leiomyoma risk among premenopausal women.