Bioequivalence & Bioavailability
نویسندگان
چکیده
The pharmacokinetics of olanzapine are linear and doseproportional within the approved dosage range from 1 mg up to 20 mg. Olanzapine is well absorbed following oral administration in both fed and fasted states . Food does not affect the rate or the extent of olanzapine absorption. Time of peak concentration ranges from 2-7 h [4,5]. Olanzapine is extensively distributed throughout the body, binding primarily to albumin (90%) and α1 -acid glycoprotein (77%). Olanzapine is eliminated extensively (40%) of the dose by first pass metabolism. Direct glucuronidation and CYP1A2 mediated oxidation are the primary metabolic pathways for olanzapine. Phenotypic difference for CYP1A2 between races has been reported. The pharmacokinetics of olanzapine are similar amongst Japanese, Chinese and Caucasians [6,7]. The most common adverse effects of olanzapine in patients receiving olanzapine in short term were weight gain, somnolence, postural hypotension, dizziness, constipation, dyspepsia, dry mouth, increased appetite, tremor, personality disorder, asthenia and akathisia [6,8].
منابع مشابه
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