A patient with polycythaemia vera associated with membranoproliferative glomerulonephritis.

Myeloproliferative disorders (MPDs) are clonal disorders of the haematopoietic stem cells. These are classified as polycythaemia vera (PV), essential thrombocythaemia (ET), chronic myeloid leukaemia (CML) and myelofibrosis (MF) depending on the main haematopoietic lineage involved. Glomerulonephritis (GN) refers to a pattern of glomerular injury based on characteristic histopathology findings. GN associated with MPDs are rare in clinical practice. Although cases of polycythaemia with concomitant GN have occasionally been reported, there are few reports regarding PV. Amongst the few reported cases, focal segmental glomerulosclerosis (FSGS) is one of the most frequent forms that has been described. As far as we know PV associated with membranoproliferative glomerulonephritis (MPGN) has not been described before.