Cancer cocktails come of age
ثبت نشده
چکیده
As tumors adapted, so did scientists. They resolved to combine targeted therapeutic agents into drug cocktails to control the evolution of resistance and thwart the persistent cancer cells, a strategy that’s finally coming to fruition. A slew of data from early-phase trials—presented by Novartis researchers and others at the American Society of Clinical Oncology (ASCO) meeting in June 2014—is the latest sign that combination therapy is coming of age.
منابع مشابه
Comparative analysis of three- and two-antibody cocktails to AMACR and basal cell markers for the immunohistochemical diagnosis of prostate carcinoma
BACKGROUND Immunohistochemistry using antibody cocktails against basal cell specific and cancer-associated markers is important in the diagnosis of prostate carcinoma in needle biopsies. We compared the usefulness for detecting prostate carcinoma of a three-marker cocktail of antibodies to α-methylacyl-CoA racemase (AMACR), p63 and cytokeratin (CK) 5 with a traditional two-marker cocktail of AM...
متن کاملPrediction of drug cocktail effects when the number of measurements is limited
Cocktails of drugs can be more effective than single drugs, because they can potentially work at lower doses and avoid resistance. However, it is impossible to test all drug cocktails drawn from a large set of drugs because of the huge number of combinations. To overcome this combinatorial explosion problem, one can sample a relatively small number of combinations and use a model to predict the...
متن کاملAlgorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells.
The standard treatment for most advanced cancers is multidrug therapy. Unfortunately, combinations in the clinic often do not perform as predicted. Therefore, to complement identifying rational drug combinations based on biological assumptions, we hypothesized that a functional screen of drug combinations, without limits on combination sizes, will aid the identification of effective drug cockta...
متن کاملCarbohydrate-based cocktails that decrease the population of Salmonella and Campylobacter in the crop of broiler chickens subjected to feed withdrawal.
The efficacy of various carbohydrate-based cocktails in reducing the number of enteropathogens in the crops of broilers subjected to feed withdrawal was examined. Market-aged broilers that had been orally challenged with Salmonella typhimurium were provided the cocktails during a 12-h feed withdrawal. After feed withdrawal, the broilers were processed, and their crops were aseptically removed a...
متن کاملAnticancer drug combinations : The next medical challenge
Since most cancers have multiple genetic alterations and molecular abnormalities, it is seldom very useful by using therapeutics of only one anticancer drug owing to refractory and drug resistance of cancer tissues. It has a long time consensus that anticancer drug cocktail instead single drugs might dramatically promote the control of cancer progresses and metastasis in most clinical cancer tr...
متن کامل