Polyclonal Anti-T Cell Antibodies in Renal Transplantation
نویسنده
چکیده
Polyclonal anti-T cell antibodies or antilymphocyte serum (ALS) are xenogeneic antihuman polyclonal antibodies, more precisely antithymocyte globulins (ATG). They are prepared by immunizing rabbits or horses with human lymphoid cells derived from the thymus. They were first prepared for clinical use in horses [1] and followed by a more potent preparation in rabbits. Despite some problems of using polyclonal ATG, they are used in organ transplantation for induction and particularly to reverse acute rejection.
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