A Replication-Defective Herpes Simplex Virus (HSV)-2 Vaccine, HSV529, is Safe and Well-Tolerated in Adults with or without HSV Infection and Induces Significant HSV-2-Specific Antibody Responses in HSV Seronegative Individuals
نویسندگان
چکیده
1343. Persistence of Immune Response to an Adjuvanted Varicella‐Zoster Virus Subunit Candidate Vaccine for up to Year 9 in Older Adults Karlis Pauksens, MD; Stephanie Volpe, MPH; Tino F. Schwarz, MD; Jan Smetana, MD PhD; Nicole Toursarkissian, MD; Lars Rombo, MD; Stéphanie Ravault, PhD; Marie-Pierre David, MSc; Adriana Bastidas, PhD and Lidia Oostvogels, MD; Uppsala University Hospital, Uppsala, Sweden, GSK, Wavre, Belgium, Central Laboratory and Vaccination Center, Stiftung Juliusspital, Wuerzburg, Germany, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic, Practice Dr. Toursarkissian, Berlin, Germany, Karolinska University Hospital, Stockholm, Sweden, GSK, Rixensart, Belgium
منابع مشابه
Immunogenicity, Protective Efficacy, and Non-Replicative Status of the HSV-2 Vaccine Candidate HSV529 in Mice and Guinea Pigs
HSV-2 vaccine is needed to prevent genital disease, latent infection, and virus transmission. A replication-deficient mutant virus (dl5-29) has demonstrated promising efficacy in animal models of genital herpes. However, the immunogenicity, protective efficacy, and non-replicative status of the highly purified clinical vaccine candidate (HSV529) derived from dl5-29 have not been evaluated. Humo...
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Herpes simplex virus type 1 (HSV-1) with a worldwide distribution has been reported in all human populations, resulting in a clinical spectrum of infections. Although HSV type 2 (HSV-2) is known as the most common cause of genital herpes, an increasing number of cases with genital herpes are caused by HSV-1. The present study aimed to discuss the changes in the epidemiology of HSV-1 infection i...
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