Rethinking causation for complex systems in biomedicine: challe
نویسندگان
چکیده
Rene Descartes (1596-1650) stripped the sclera and choroid off the eye of an ox to perform a projection experiment onto a piece of paper. This proved that the retina initially sees an inverted image. Descartes thought of the brain as a machine with fibres running from the eyes like optical cables. These formed a rudimentary visual pathway. The inner soul within the brain then viewed the image transferred to it along the pathway by vibrational forces.
منابع مشابه
Causation and Collaboration for Stroke Research
Abstract—The pathophysiology of stroke is complex. Adaptive and maladaptive signalling occurs between multiple cell types in the brain. There is crosstalk between central and systemic responses. And there are overlapping pathways during initial injury and subsequent repair. These numerous feed-forward and feed-back interactions have made it difficult to translate experimental discoveries into c...
متن کامل2013 Thomas Willis Award Lecture: Causation and collaboration for stroke research.
The pathophysiology of stroke is complex. Adaptive and maladaptive signalling occurs between multiple cell types in the brain. There is crosstalk between central and systemic responses. And there are overlapping pathways during initial injury and subsequent repair. These numerous feed-forward and feed-back interactions have made it difficult to translate experimental discoveries into clinical a...
متن کاملReasoning over genetic variance information in cause-and-effect models of neurodegenerative diseases
The work we present here is based on the recent extension of the syntax of the Biological Expression Language (BEL), which now allows for the representation of genetic variation information in cause-and-effect models. In our article, we describe, how genetic variation information can be used to identify candidate disease mechanisms in diseases with complex aetiology such as Alzheimer's disease ...
متن کاملYoung Investigator Perspectives. Rethinking the biomedical postdoc: but first let's get the data.
Dr. Joseph F. Pierre PhD is a postdoctoral fellow at the University of Chicago, where he studies the interplay between nutrition, the microbiome, and the enteric immune and neuronal systems. His Young Investigator Perspective, “Rethinking The Biomedical Postdoc: But First Let’s Get The Data,” highlights the challenges faced by postdoctoral fellows in biomedical sciences and emphasizes the impor...
متن کاملP-122: The Effect of Beta Globin Intron on Human LH Hormone Expression in CHO Cells
Background Luteinizing hormone (LH) is a heterodimeric glycoprotein composed of alpha and beta subunits.This hormone is secreted from the pituitary gland. LH, in women triggers Menstrual cycle and ovulation. In men, LH stimulates production of testosterone, which plays a specialized role in sperm production. Up to day, LH hormone have produced in different ways such as codon optimization and al...
متن کامل