(HDL), and triglycerides (TG) with plasma homocysteine levels and with seven variants of homocysteine metabolism: dihydrofolate reductase (DHFR) c.594+59del19bp, cystathionine beta-synthase (CBS) c.844_855ins68, methionine synthase

BACKGROUND/AIM: Recent studies have suggested a relation of homocysteine with lipid metabolism. The aim of this study was to analyze a possible genetic basis for such a relation in 504 individuals including 135 consecutive Caucasian patients diagnosed with cerebrovascular disease as well as the patients’ healthy spouses (n = 100) and offspring (n = 269). METHODS: We analyzed the association of plasma levels of lipoprotein(a), total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglycerides with plasma homocysteine levels and with the following 7 variants of homocysteine metabolism: dihydrofolate reductase c.594 + 59del19bp, cystathionine �-synthase c.844855ins68, methioninesynthasec.2756AG, methylenetetrahydrofolatereductasec.677CTandc.1298AC, reducedfolatecarrier1c.80GA, andtranscobalamin2(Tc2)c.776CG.RESULTS : LinearregressionanalysisshowedanassociationofTc2c.776CGwithLDL(p = 0.010), HDL(p = 0.009), andTG(p = 0.007), withtheGalleleofTc2c.776CGassociatedwithanunfavorablebloodlipidprofile.Moreover, theGalleleofTc2c.776CGwasassociatedwithhigherhomocysteineplasmalevelsinthesubgroupofpatients(p = 0.013, 1−wayANOV A).CONCLUSION : Thesedatasupportthehypothesisthatalterationsinhomocysteinemetabolismandanunfavorablebloodlipoproteinprofilemayhaveacommongeneticbasis.Suchconditionsmayberelevantforstudiesinvestigatingindependentriskfactorsforvasculardisease.Copyrightľ2010S.KargerAG, Basel. DOI: https://doi.org/10.1159/000320418 Posted at the Zurich Open Repository and Archive, University of Zurich ZORA URL: https://doi.org/10.5167/uzh-43010 Accepted Version Originally published at: Semmler, A; Farmand, S; Moskau, S; Stoffel-Wagner, B; Linnebank, M (2010). The G allele of transcobalamin 2 c.776C→G is associated with an unfavorable lipoprotein profile. Annals of Nutrition Metabolism, 57(2):112-115. DOI: https://doi.org/10.1159/000320418 The G-allele of transcobalamin 2 c.776C>G is associated with an unfavorable lipoprotein profile Alexander Semmler, Susan Farmand, Susanna Moskau, Birgit Stoffel-Wagner, Michael Linnebank University Zurich, Department of Neurology, Switzerland University Bonn, Department of Neurology, Germany University Bonn, Institute of Clinical Chemistry and Pharmacology, Germany Correspondence: PD Dr. Michael Linnebank, University of Zurich, Department of Neurology, Frauenklinikstrasse 26, CH-8091 Zurich, Switzerland, phone: (41) 44 2555544; fax: (41) 44 2554507, E-Mail: [email protected] Running title: Tc2 c.776C>G is associated with plasma lipoproteins