Sharp wave - associated synchronized inputs from the piriform cortex activate olfactory tubercle 1 neurons during slow - wave sleep 2 3
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چکیده
Sharp wave-associated synchronized inputs from the piriform cortex activate olfactory tubercle 1 neurons during slow-wave sleep 2 3 Kimiya Narikiyo Abstract 18 During slow-wave sleep, anterior piriform cortex neurons show highly synchronized discharges that 19 accompany olfactory cortex sharp waves (OC-SPWs). The OC-SPW-related synchronized activity of 20 anterior piriform cortex neurons travel down to the olfactory bulb and is thought to be involved in 21 the reorganization of bulbar neuronal circuitry. However, influences of the OC-SPW-related activity 22 on other regions of the central olfactory system are still unknown. Olfactory tubercle is an area of 23 OC and part of ventral striatum that plays a key role in reward-directed motivational behaviors. Here 24 we show that in freely behaving rats olfactory tubercle receives OC-SPW-associated synchronized 25 inputs during slow-wave sleep. Local field potentials in the olfactory tubercle showed SPW-like 26 activities that were in synchrony with OC-SPWs. Single unit recordings showed that a subpopulation 27 of olfactory tubercle neurons discharged in synchrony with OC-SPWs. Furthermore, correlation 28 analysis of spike activity of anterior piriform cortex and olfactory tubercle neurons revealed that the 29 discharges of anterior piriform cortex neurons tended to precede those of olfactory tubercle neurons. 30 Current source density analysis in urethane-anesthetized rats indicated that the current sink of the 31 OC-SPW-associated input was located in the layer III of the olfactory tubercle. These results indicate 32 that OC-SPW-associated synchronized discharges of pirifrom cortex neurons travel to the deep layer 33 of the olfactory tubercle, and drive discharges of olfactory tubercle neurons. The entrainment of 34 olfactory tubercle neurons in the OC-SPWs suggests that OC-SPWs coordinate reorganization of 35 neuronal circuitry across wide areas of the central olfactory system including olfactory tubercle 36 during slow-wave sleep.
منابع مشابه
Sharp wave-associated synchronized inputs from the piriform cortex activate olfactory tubercle neurons during slow-wave sleep.
During slow-wave sleep, anterior piriform cortex neurons show highly synchronized discharges that accompany olfactory cortex sharp waves (OC-SPWs). The OC-SPW-related synchronized activity of anterior piriform cortex neurons travel down to the olfactory bulb and is thought to be involved in the reorganization of bulbar neuronal circuitry. However, influences of the OC-SPW-related activity on ot...
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