Correction to ‘Identification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomes’
نویسندگان
چکیده
to 'Identification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomes'. (c) mutant no. additive mutations in region 2 regions of TcTIM scheme of different amino acids in region 2
منابع مشابه
Identification of the critical residues responsible for differential reactivation of the triosephosphate isomerases of two trypanosomes
The reactivation of triosephosphate isomerase (TIM) from unfolded monomers induced by guanidine hydrochloride involves different amino acids of its sequence in different stages of protein refolding. We describe a systematic mutagenesis method to find critical residues for certain physico-chemical properties of a protein. The two similar TIMs of Trypanosoma brucei and Trypanosoma cruzi have diff...
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Proteins with great sequence similarity usually have similar structure, function and other physicochemical properties. But in many cases, one or more of the physicochemical or functional characteristics differ, sometimes very considerably, among these homologous proteins. To better understand how critical amino acids determine quantitative properties of function in proteins, the responsible res...
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For a better comprehension of the structure-function relationship in proteins it is necessary to identify the amino acids that are relevant for measurable protein functions. Because of the numerous contacts that amino acids establish within proteins and the cooperative nature of their interactions, it is difficult to achieve this goal. Thus, the study of protein-ligand interactions is usually f...
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