Computational approaches to metabolic engineering utilizing systems biology and synthetic biology
نویسنده
چکیده
Metabolic engineering modifies cellular function to address various biochemical applications. Underlying metabolic engineering efforts are a host of tools and knowledge that are integrated to enable successful outcomes. Concurrent development of computational and experimental tools has enabled different approaches to metabolic engineering. One approach is to leverage knowledge and computational tools to prospectively predict designs to achieve the desired outcome. An alternative approach is to utilize combinatorial experimental tools to empirically explore the range of cellular function and to screen for desired traits. This mini-review focuses on computational systems biology and synthetic biology tools that can be used in combination for prospective in silico strain design.
منابع مشابه
Synthetic biology and regulatory networks: where metabolic systems biology meets control engineering.
Metabolic pathways can be engineered to maximize the synthesis of various products of interest. With the advent of computational systems biology, this endeavour is usually carried out through in silico theoretical studies with the aim to guide and complement further in vitro and in vivo experimental efforts. Clearly, what counts is the result in vivo, not only in terms of maximal productivity b...
متن کاملSystems metabolic engineering strategies for the production of amino acids
Systems metabolic engineering is a multidisciplinary area that integrates systems biology, synthetic biology and evolutionary engineering. It is an efficient approach for strain improvement and process optimization, and has been successfully applied in the microbial production of various chemicals including amino acids. In this review, systems metabolic engineering strategies including pathway-...
متن کاملBiomodel Engineering - From Structure to Behavior
Biomodel engineering is the science of designing, constructing and analyzing computational models of biological systems. It forms a systematic and powerful extension of earlier mathematical modeling approaches and has recently gained popularity in systems biology and synthetic biology. In this brief review for systems biologists and computational modelers, we introduce some of the basic concept...
متن کاملA new approach to an old problem: synthetic biology tools for human disease and metabolism.
The field of synthetic biology seeks to develop engineering principles for biological systems. Along these lines, synthetic biology can address human metabolic disease through the development of genetic approaches to the study and modification of metabolism. The re-engineering of natural metabolic states provides fundamental understanding of the integrated components underlying dysfunctional me...
متن کاملSystems biology.
Vassily Hatzimanikatis is an Associated Professor of Computational Systems Biotechnology at Ecole Polytechnique Federale de Lausanne (EPFL), Switzerland. Before this he worked in DuPont, Cargill, and Northwestern University. He holds a Diploma in Chemical Engineering (1991) from the University of Patras, Greece, and a PhD in Biochemical Engineering (1996) from the California Institute of Techno...
متن کامل