Chronic Treatment by L-NAME differently Affects Morris Water Maze Tasks in Ovariectomized and Naïve Female Rats
نویسندگان
چکیده
to ovariectomized (OVX) subjects has been shown in many studies to be associated with more rapid acquisition of memory tasks (Wallace et al., 2006). It has also been suggested that estrogen replacement therapy may help to reduce the risk and severity of Alzheimer disease in postmenopausal women (Gibbs, 2000; Savonenko and Markowska, 2003). The effects of estrogen on learning and memory may be due to its interaction with cho
منابع مشابه
Chronic Treatment by L-NAME differently Affects Morris Water Maze Tasks in Ovariectomized and Naïve Female Rats
Introduction: The role of ovarian hormones and nitric oxide (NO) in learning and memory and their interaction has been widely investigated. The present study carried out to evaluate different effect of L-NAME on spatial learning and memory of ovariectomized (OVX) and sham operated rats. Methods: 32 rats were divided into 4 groups: 1) Sham 2) OVX 3) Sham-LN and 4) OVX-LN. The animals of groups 3...
متن کاملEffect of Acute administration of Cisplatin on memory, motor learning, balance and explorative behaviours in Rats
Introduction: For some cancer survivors chemotherapy treatment is associated with lasting motor and cognitive impairments, long after treatment cessation. Cisplatin as an anti-neoplastic agent is extremely toxic and can cause severe tissue damage. In the present study, we elucidated alteration in performance of hippocampus- and cerebellum-related behaviors following acute cisplatin treatmen...
متن کاملChronic treatment with the nitric oxide synthase inhibitor, L-NAME, attenuates estradiol-mediated improvement of learning and memory in ovariectomized rats
INTRODUCTION The role of ovarian hormones and nitric oxide in learning and memory has been widely investigated. OBJECTIVE The present study was carried out to evaluate the effect of the nitric oxide synthase (NOS) inhibitor, N (G)-nitro-L-arginine methyl ester (L-NAME), on the ability of estradiol to improve learning in OVX rats using the Morris water maze. METHODS Forty rats were divided i...
متن کاملEffect of Lead (Pb2+) Exposure in Female Pregnant Rats and Their Offspring on Spatial Learning and Memory in Morris Water Maze
Lead (Pb2+) is a well known neurotoxin that was frequently found in the environment and chronic exposure to lead has been matter of public health. In the present study the effect of lead on spatial memory in developmentally exposed rats and their dams in Morris water maze task were investigated. Female rats were divided into three groups and two groups exposed to 250 and 750 part per million (p...
متن کاملEffect of Lead (Pb2+) Exposure in Female Pregnant Rats and Their Offspring on Spatial Learning and Memory in Morris Water Maze
Lead (Pb2+) is a well known neurotoxin that was frequently found in the environment and chronic exposure to lead has been matter of public health. In the present study the effect of lead on spatial memory in developmentally exposed rats and their dams in Morris water maze task were investigated. Female rats were divided into three groups and two groups exposed to 250 and 750 part per million (p...
متن کامل