Composition of Human Trabecular Bone Changes with Age and Differs between Anatomical Locations; Evaluation with FTIR
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Evaluation with FTIR +Turunen, M J; Jurvelin, J S; Kröger, H; Isaksson, H +University of Eastern Finland, Kuopio, Finland, Kuopio University Hospital, Kuopio, Finland, Lund University, Lund, Sweden [email protected] INRODUCTION: Bone structure and composition adapt to its mechanical loading environment [1] and show variations with age [2,3]. Trabecular bone is highly metabolically active, and is expected to change its composition of the organic and inorganic matrices during remodeling. Hence, the molecular composition of trabecular bone may vary between different anatomical locations due to different mechanical loading and remodeling rates. Fourier transform infrared (FTIR) microspectroscopy provides a tool for fast measurements of the molecular composition of bone [2-6]. Our aim was to compare the molecular composition of human trabecular bone from three anatomical locations with different mechanical loading environment. Moreover, the changes in molecular composition of bone with age during adult life were investigated.
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