Leukocytes and Leukocytic Disease

The production of antibody against human leukocytic pyrogen.

Human peripheral blood leukocytes were stimulated with killed staphylococci in vitro to release leukocytic pyrogen (LP). Supernates from these stimulated leukocytes were concentrated, emulsified in Freund's complete adjuvant, and injected intradermally into rabbits. After seven monthly booster injections, rabbit antiserum destroyed the pyrogenic activity of human LP, and the titer of this neutr...

Species Specificity of Leukocytic Pyrogens

Polymorphonuclear neutrophilic leukocytes of the dog, cat, and goat release leukocytic pyrogen under the same conditions as the heterophile polymorphonuclear leukocytes of the rabbit. The characteristics of the febrile response to an intravenous injection of homologous leukocytic pyrogen in all four species are very similar: a brisk monophasic fever reaching a peak between 30 and 50 min with sm...

Vitamin B 12-binding Protein of Leukocytes

Much evidence suggests that granulocytes are a major source of serum vitamin B12-binding protein (BBP). The latter has three components: a-iglobulin BBP (Transcobalamin I, TC I), fl-globulin BBP (TC II), and a recently described third BBP. Granulocytic BBP has appeared to be identical to TC I except in electrophoretic mobility. In the present study, the dominant BBP of leukocyte extracts from s...

Leukocytic Hydrolytic Enzymes in Acute Stage of Chd

ORIGINAL CONTRIBUTIONS free radicals. If free radicals remain in the phosphate and reduced glutathione were body for longer time, they can damage body obtained from Sisco Co. All other chemicals STUDY OF LEUKOCYTIC HYDROLYTIC ENZYMES IN PATIENTS cells. AMI is frequently associated with and solvents used were of analytical reagent WITH ACUTE STAGE OF CORONARY HEART DISEASE leukocytosis and an el...

Comparison of Heinatologic and Febrile Response to Endotoxin in Man

By SHELDON M. WOLFF, MELVIN RUBENSTEIN, JOHN H. MULHOLLAND AND DAVID W. ALLING T HE PROFOUND HEMATOLOGIC alterations evoked in experimental animals following endotoxin administration have been considered to play a major role in the pathogenesis of some of the biologic effects produced by these lipopolysaccharides. Marked leukopenia, primarily granulocytopenia, and subsequent granulocytosis as w...

On the interaction of dead leukocytic nuclei, L. E. factor and living leukocytes in the L. E. cell phenomenon.