Surgical therapy of vitiligo: current status.
نویسنده
چکیده
Vitiligo is an acquired condition that presents as sharply demarcated white macules. It affects 1%-2% people of all races regardless of sex and age. Although the disease does not have any systemic complications, it is of great cosmetic concern, particularly in darker skinned individuals, as in Indians, where it creates psychological problems due to the stigma attached to it. In vitiligo, there is a partial or total destruction of melanocytes, initially only of the epidermis, and later even of the hair follicle, which acts as a reservoir for providing melanocytes during repigmentation. Hence, in patients with vitiligo, the existing melanocytes need to be activated. While medical therapies are the primary treatment, there are some patients refractory to medical treatment. In such patients, surgical therapies can be used either alone or in conjunction with medical therapy to achieve repigmentation provided the disease is stable. Stability has been defined by different authors as a period varying from 6 months to 2 years during which the existing lesions should not have enlarged, no new lesions should have developed, and there should be no koebnerization. It is best to confirm the stability of the disease by doing trial test grafting in a small vitiliginous area 11⁄2-2 months before undertaking surgery of the entire lesion.
منابع مشابه
Current and emerging therapy for the management of vitiligo
Vitiligo is an acquired cutaneous disorder of pigmentation, with an incidence of 0.5% to 2% worldwide. There are three major hypotheses for the pathogenesis of vitiligo that are not exclusive of each other: biochemical/cytotoxic, neural and autoimmune. Recent data provide strong evidence supporting an autoimmune pathogenesis of vitiligo. As vitiligo can have a major effect on quality of life, t...
متن کاملCCID_3627_Van Geel.indd
Correspondence: Nanny van Geel Department of Dermatology, De Pintelaan 185, 9000 Ghent, Belgium Tel +32 9 332 22 87 Fax +32 9 332 49 96 Email [email protected] Abstract: Vitiligo is an acquired cutaneous disorder of pigmentation, with an incidence of 0.5% to 2% worldwide. There are three major hypotheses for the pathogenesis of vitiligo that are not exclusive of each other: biochemical/cyt...
متن کاملTreatment of segmental vitiligo with normal-hair follicle autograft
Background: Segmental vitiligo is a small subset albeit persistent form of focal vitiligo with dermatomal distribution and resistant to medical therapy. In recent years, surgical therapy as hair follicle autograft transplantation has been a hot topic in management of segmental vitiligo. In this study, we evaluated the efficacy of this method in segmental vitiligo lesions. Methods: Th...
متن کاملA comparison between systemic psoralen plus ultraviolet A therapy and topical clobetasol in the treatment of vitiligo
Background: Topical corticosteroids and oral psoralen plus ultraviolet A radiation (PUVA therapy) are two common treatment methods for vitiligo. The aim of this study was to compare the efficacy, complications and patterns of repigmentation of these two methods. Methods: This prospective randomized clinical trial was conducted from July 2007 to October 2008. Patients with disseminated vitiligo ...
متن کاملJ Turk Acad Dermatol 2015; 9 (1): 1591r1
Background: Vitiligo is an acquired idiopathic pigmentary skin disorder characterized by sharply demarcated milky white macules with variable size and shape. It has an estimated worldwide incidence of 0.5-4% and occurs in half of the patients before the age of 20 years. Since exact pathogenic mechanism is unknown, several proposed hypotheses are alternation of cellular and humoral immunity, mel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Indian journal of dermatology, venereology and leprology
دوره 71 5 شماره
صفحات -
تاریخ انتشار 2005