Exceedingly Efficient Synthesis of (±)-Grandifloracin and Acylated Analogues.
نویسندگان
چکیده
A highly efficient regio- and stereoselective total synthesis of (±)-grandifloracin via a tandem dearomative epoxidation/spontaneous Diels-Alder cyclodimerization from salicylic acid in only four steps is reported. The synthetic route allows for late-stage diversification of the core structure to give ready access to analogues of this promising agent against pancreatic cancer.
منابع مشابه
The enone motif of (+)-grandifloracin is not essential for 'anti-austerity' antiproliferative activity.
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ورودعنوان ژورنال:
- Organic letters
دوره 17 12 شماره
صفحات -
تاریخ انتشار 2015