Combined therapy with desferrioxamine and deferiprone in thalassemic patients: effect on urinary iron excretion.
نویسندگان
چکیده
Sanna Kotisaari,* Jarkko Romppanen,* Ulla Ågren,° Sakari Eskelinen,* Kari Punnonen* *Department of Clinical Chemistry, Kuopio University Hospital, PL 1777, Kuopio; °Students’ Health Service, Kuopio University, PL 1777, 70211 Kuopio, Finland
منابع مشابه
Complications of Combined Treatment with Deferiprone and Desferrioxamine in Thalassemic Patients
Although successful iron chelation with deferiprone is associated with significant complications, patient’s compliance with medication regimens is of a high priority. The present study did evaluate the complications and compliance of domestically-manufactured deferiprone combined with desferrioxamine for iron chelation therapy. A total of 32 major beta thalassemic patients with cardiomyopathy w...
متن کاملCombined Therapy with Deferiprone and Desferrioxamine as Compared to Desferasirox on Ventricular Function in Thalassemia Major Patients
Abstract Background Myocardial iron overload is the leading cause of death in patients with beta-thalassemia major. Combined therapy with deferiprone(DFP) and desferrioxamine (DFO)were suggested to be more effective than deferasirox(DFX) for removing heart iron. Deferasirox has recently been made available, but its long-term efficacy on cardiac function has not yet been established. Our study...
متن کاملComparative efficacy of desferrioxamine, deferiprone and in combination on iron chelation in thalassemic children.
OBJECTIVE Ascertainment of an appropriate strategy of iron chelation for multi-transfused thalassemic children in developing countries. DESIGN Prospective study from May 2000 to April 2001. SETTING Urban tertiary care center. METHODS Thirty thalassemic children having received more than 20 blood transfusions and a serum ferritin greater than 1500 ng/ml were enrolled and randomized into th...
متن کاملCombined therapy with deferiprone and desferrioxamine in thalassemia major.
BACKGROUND AND OBJECTIVES Effective and convenient iron chelation remains one of the main targets of clinical management of thalassemia major. The combined treatment with desferrioxamine and deferiprone could have an increased chelation efficacy and sometimes allow drug doses and toxicity to be reduced and the number of days of desferrioxamine infusion to be decreased, improving compliance and ...
متن کاملTimed non-transferrin bound iron determinations probe the origin of chelatable iron pools during deferiprone regimens and predict chelation response.
BACKGROUND Plasma non-transferrin bound iron refers to heterogeneous plasma iron species, not bound to transferrin, which appear in conditions of iron overload and ineffective erythropoiesis. The clinical utility of non-transferrin bound iron in predicting complications from iron overload, or response to chelation therapy remains unproven. We undertook carefully timed measurements of non-transf...
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ورودعنوان ژورنال:
- Haematologica
دوره 88 12 شماره
صفحات -
تاریخ انتشار 2003