Neurobiology of Disease D2 Dopamine Receptors Colocalize Regulator of G-Protein Signaling 9-2 (RGS9-2) via the RGS9 DEP Domain, and RGS9 Knock-Out Mice Develop Dyskinesias Associated with Dopamine Pathways
نویسندگان
چکیده
Abraham Kovoor,1,6 Petra Seyffarth,2 Jana Ebert,2 Sami Barghshoon,1 Ching-Kang Chen,3 Sigrid Schwarz,1,2 Jeffrey D. Axelrod,4 Benjamin N. R. Cheyette,5 Melvin I. Simon,1 Henry A. Lester,1 and Johannes Schwarz1,2 1Division of Biology, California Institute of Technology, Pasadena, California 91125, 2Department of Neurology, University of Leipzig, 04103 Leipzig, Germany, 3Departments of Ophthalmology and Visual Sciences and Human Genetics, University of Utah, Salt Lake City, Utah 84112, 4Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, 5Nina Ireland Laboratory of Developmental Neurobiology and Department of Psychiatry and 6The Center for Neurobiology and Psychiatry, University of California, San Francisco, San Francisco, California 94143-0984
منابع مشابه
Adaptive Gene Regulation in the Striatum of RGS9-Deficient Mice
BACKGROUND RGS9-deficient mice show drug-induced dyskinesia but normal locomotor activity under unchallenged conditions. RESULTS Genes related to Ca2+ signaling and their functions were regulated in RGS9-deficient mice. CONCLUSION Changes in Ca2+ signaling that compensate for RGS9 loss-of-function can explain the normal locomotor activity in RGS9-deficient mice under unchallenged conditions...
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Two isoforms of the GTPase-activating protein, regulator of G protein signaling 9 (RGS9), control such fundamental functions as vision and behavior. RGS9-1 regulates phototransduction in rods and cones, and RGS9-2 regulates dopamine and opioid signaling in the basal ganglia. To determine their functional differences in the same intact cell, we replaced RGS9-1 with RGS9-2 in mouse rods. Surprisi...
متن کاملThe DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.
DEP (for Disheveled, EGL-10, Pleckstrin) homology domains are present in numerous signaling proteins, including many in the nervous system, but their function remains mostly elusive. We report that the DEP domain of a photoreceptor-specific signaling protein, RGS9 (for regulator of G-protein signaling 9), plays an essential role in RGS9 delivery to the intracellular compartment of its functioni...
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The regulator of G-protein signaling (RGS) modulates the functioning of heterotrimeric G protein. RGS9-2 is highly expressed in the striatum and plays a role in modulating dopaminergic receptor-mediated signaling cascades. Previous studies suggested that the RGS9 gene might contribute to the susceptibility to psychotic diseases. Therefore, we investigated the association between the RGS9 gene a...
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