Effect of Organic Selenium Compounds on the Activity of Glutathione Peroxidase and Superoxide Dismutase in Selected Mouse Tissues
نویسنده
چکیده
The aim of the study was to determine the activity of antioxidative enzymes GPH-Px and SOD as well as selenium concentration and distribution in mice treated with selenium compounds. Organic selenium compounds obtained in our laboratory: 4-(o-tolyl-) selenosemicarbazide of p-chlorobenzoicacid and 3-(p-chlorobenzoylamino-)-2-(o-tolylimino-) 4-phenyl-4-selenazoline were administrated to mice in a dose of 5x10 mg/1 g body weight for 10 d. Results were compared with control group without supplementation and with the group in which sodium selenite was given. A correlation was observed between GPH-Px level and Se distribution in mouse tissues. Our investigations let presume that the obtained organic compounds can be good and assimilable selenium forms.
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