A Comparative Study of Intravenous Ondansetron and Granisetron for Prevention of Nausea and Vomiting Following Laparoscopic Cholecystectomy

Laparoscopic cholecystectomy is associated with significantly high rate of post operative nausea and vomiting (PONV). This study was designed to compare the effectiveness of Ondansetron with that of Granisetron for prevention of PONV after laparoscopic cholecystectomy. In a randomized, prospective study, 100 patients were selected and randomly divided into two groups of 50 each. Group one received Ondansetron 4mg intravenously and group two received 2mg Granisetron intravenously before induction. Perioperative anaesthetic care was standardized in all patients. They were then observed for 24 hours after administration of the study drug. A complete response (defined as no PONV and no need for another rescue antiemetic) was achieved in 66% of the patients given Ondansetron and 82% of the patients given Granisetron. Increased incidence of side effects seen in Ondansetron group than Granisetron group. This study concludes that Granisetron is slightly more effective than Ondansetron as prophylactic antiemetic in laparoscopic cholecystectomy.