[Bone mineral density and its association with body composition and metabolic biomarkers of insulin-glucose axis, bone and adipose tissue in women].

INTRODUCTION There are few studies integrating the common causes of osteoporosis and obesity (disorders of body composition). A first step is to investigate correlations between their biological phenotypes to determine their common integrative physiology. OBJECTIVE To correlate the variation of bone mineral density with phenotypes of body composition and biomarkers of bone physiology, insulin-glucose axis, and adipose tissue. METHODS Cross-sectional study of 75 women (aged 18-45 years). MEASUREMENTS Body mass index, waist, fat mass, lean mass (dual-energy X-ray absorptiometry), glucose, insulin, osteocalcin, leptin, tumor necrosis factor alpha. STATISTICAL ANALYSIS multivariate general linear model, SPSS v.22, p<0.05. RESULTS Age: 32.08±7.33. Bone mineral content multivariate general linear model 1 with two phenotypes excluded (glucose, insulin): osteocalcin (β=-0.228, p=0.011), lean mass (β=0.606, p=0.001) and fat mass (β=1.237, p=0.001) in 62.0%. The bone mineral density multivariate general linear model 2 with three phenotypes excluded (body mass index, glucose, tumor necrosis factor alpha): insulin (β=0.250, p=0.024), osteocalcin (β=-0.362, p=0.001), lean mass (β=0.512, p=0.001) and fat mass (β=0.701, p=0.001) in 46.3%. CONCLUSIONS Results show that body composition with an increased lean mass is beneficial to bone. This study reaffirms the importance of performing regular exercise to prevent muscle loss.