S-Linked sialyloligosaccharides bearing liposomes and micelles as influenza virus inhibitors.
نویسندگان
چکیده
An efficient, homogeneous synthesis of phospholipid conjugation of S-Neu5Acα2-6Galβ1-4GluNAcβ1-3 (3) and its 6-sulphate analogue 4 has been developed. The self-assembled micelles and liposomes of these trisaccharides formed in solution were found to be inhibitors interfering with the entry of the H1N1 influenza virus into MDCK cells. Compound 3 bearing a liposome and a micelle displayed superior inhibitory activity than its 6-sulfate congener 4 in both the virus neutralization assay and the hemagglutination inhibition assay.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 13 47 شماره
صفحات -
تاریخ انتشار 2015